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Courses / Graduate School / BIOSTAT

BIOSTAT 905

Linear Models and Inference

Pixu Shi

Description from DukeHub

Introduction to linear models and linear inference from the coordinate-free viewpoint. Topics: identifiability and estimability, key properties of and results for finite-dimensional vector spaces, linear transformations, self-adjoint transformations, spectral theorem, properties and geometry of orthogonal projectors, Cochran's theorem, estimation and inference for normal models, distributional properties of quadratic forms, minimum variance linear unbiased estimation, Gauss-Markov theorem and estimation, calculus of differentials, analysis of variance and covariance. Prerequisite: Biostatistics 906. Instructor consent required.

Skills

AI-resilient: 0 of 5

  • No: Physical, lab or field work
  • No: Live work with people
  • No: Judgment someone is accountable for
  • No: A craft you practice with your hands or body
  • No: Small, in-person format

The checks lean on Microsoft Research, Working with AI (2025), which found generative AI applies least to physical work and hands-on work with people. A signal, not a promise. How the score works

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